Protein biomarkers predict dementia 15 years before diagnosis

Of 1,463 proteins analysed, aided by with a type of artificial intelligence known as machine learning, 11 proteins were identified and combined as a protein panel, which the researchers have shown to be highly accurate at predicting future dementia. Further incorporation of conventional risk factors of age, sex, education level and genetics, showed for the first time the high accuracy of the predictive model, measured at over 90%*, indicating its potential future use in community-based dementia screening programs.

New theory claims to unite Einstein’s gravity with quantum mechanics

Modern physics is founded upon two pillars: quantum theory on the one hand, which governs the smallest particles in the universe, and Einstein’s theory of general relativity on the other, which explains gravity through the bending of spacetime. But these two theories are in contradiction with each other and a reconciliation has remained elusive for over a century.

The prevailing assumption has been that Einstein’s theory of gravity must be modified, or “quantized,” in order to fit within quantum theory. This is the approach of two leading candidates for a quantum theory of gravity, string theory and loop quantum gravity.

But a new theory, developed by Professor Jonathan Oppenheim (UCL Physics & Astronomy) and laid out in a paper in Physical Review X, challenges that consensus and takes an alternative approach by suggesting that spacetime may be classical—that is, not governed by quantum theory at all.

Instead of modifying spacetime, the theory—dubbed a “postquantum theory of classical gravity”—modifies quantum theory and predicts an intrinsic breakdown in predictability that is mediated by spacetime itself. This results in random and violent fluctuations in spacetime that are larger than envisaged under quantum theory, rendering the apparent weight of objects unpredictable if measured precisely enough.

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